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Cyclohexadepsipeptides from the Filamentous Fungus Acremonium sp. BCC 2629
Author(s) -
Bunyapaiboonsri Taridaporn,
Vongvilai Pornrapee,
Auncharoen Patchanee,
Isaka Masahiko
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100482
Subject(s) - chemistry , acremonium , fungus , hydrolysate , plasmodium falciparum , stereochemistry , microbiology and biotechnology , mycobacterium tuberculosis , biochemistry , tuberculosis , botany , biology , hydrolysis , immunology , medicine , pathology , malaria
Seven new cyclohexadepsipeptides, beauvenniatins F, G 1 , G 2 , G 3 , H 1 , H 2 , and H 3 ( 1 – 7 , resp.), were isolated from cultures of the fungus Acremonium sp. BCC 2629. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations were addressed by HPLC analyses of their acid hydrolysates. Their biological activities were evaluated against Mycobacterium tuberculosis H37Ra and Plasmodium falciparum K1; the respective MIC and IC 50 values were in the micromolar range.