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A Novel Catalyst‐Free One‐Pot Synthesis of Some New N ‐( α ‐Hydroxybenzyl)formamides by Treatment of 2,2‐Dichloroaziridines with Dimethyl Sulfoxide and Water under Neutral Conditions
Author(s) -
Naeimi Hossein,
Rabiei Khadijeh
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100453
Subject(s) - formamides , chemistry , dimethyl sulfoxide , catalysis , aqueous solution , aqueous medium , organic chemistry , combinatorial chemistry , medicinal chemistry
A novel, mild, and efficient method is reported for the preparation of new N ‐( α ‐hydroxybenzyl)formamides in excellent yields and appropriate reaction times through the reaction of 2,2‐dichloroaziridines with aqueous DMSO as the O ‐ donor under neutral conditions at 70–85°.
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