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Preparation of Isotope Labeled/Unlabeled Key Intermediates in 2‐Methyl‐ D ‐erythritol 4‐Phosphate Terpenoid Biosynthetic Pathway
Author(s) -
Li Heng,
Dai ShaoBo,
Gao WenYun
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100396
Subject(s) - chemistry , terpenoid , erythritol , terpene , enzyme , biosynthesis , stereochemistry , phosphate , biochemistry , organic chemistry
Naturally occurring terpenes constitute one of the largest groups of natural products with complicated and variable structures, and a great number of important biological activities. The 2‐methyl‐ D ‐erythritol 4‐phosphate (MEP) pathway is a newly found and established biosynthetic route for terpenoids, and all the enzymes involved in this pathway can be used as targets for the screening of antibiotics. Progress in chemical and enzymatic preparation of the key intermediates in this pathway is reviewed with the emphasis on the synthesis of 1‐deoxy‐ D ‐xylulose 5‐phosphate and 2‐methyl‐ D ‐erythritol 4‐phosphate with isotope labels.