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Designing and Synthesis of Novel Amidated Fentanyl Analogs
Author(s) -
Haghighatnia Yaghoub,
Balalaie Saeed,
Bijanzadeh Hamid Reza
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100392
Subject(s) - chemistry , piperidine , amide , ugi reaction , combinatorial chemistry , fentanyl , scaffold , drug discovery , stereochemistry , organic chemistry , isocyanide , pharmacology , biochemistry , biomedical engineering , medicine
Some new amidated fentanyl (= N ‐[1‐(2‐phenylethyl)piperidin‐4‐yl]‐ N ‐phenylpropanamide) analogs with a 4‐( N ‐phenylamido)piperidine scaffold and additional amide bonds have been designed and synthesized through Ugi four‐component reaction ( Ugi ‐4CR). Good‐to‐high yields, diversity‐oriented synthesis, and possible applications in drug discovery are advantages of this approach.