Premium
Abieseconordines A and B, Two Novel Norditerpenoids with a 18‐Nor‐5,10 : 9,10‐disecoabietane Skeleton from Abies forrestii
Author(s) -
Yu Ping,
Zhang ShouDe,
Li YongLi,
Yang XianWen,
Zeng HuaWu,
Li HongLin,
Zhang WeiDong
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100341
Subject(s) - chemistry , skeleton (computer programming) , circular dichroism , stereochemistry , absolute configuration , phytochemical , carbon skeleton , two dimensional nuclear magnetic resonance spectroscopy , biochemistry , computer science , programming language
A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B ( 1 and 2 ) are the first two examples of norditerpenes with a novel 18‐nor‐5,10 : 9,10‐disecoabietane skeleton. Their structures were established mainly by analysis of 1D‐ and 2D‐NMR spectroscopic data. In addition, electronic circular‐dichroism calculations and molecular‐orbital analysis were utilized to confirm the absolute configuration of 1 . Both compounds exhibited a potent effect in a bioassay inhibiting LPS‐stimulated NO production in RAW264.7 macrophages.