‘Click Synthesis’ of Some Novel O ‐Substituted Oximes Containing 1,2,3‐Triazole‐1,4‐diyl Residues as New Analogs of β ‐Adrenoceptor Antagonists

The ‘click synthesis’ of some novel O ‐substituted oximes, 7a – 7t , which contain 1,2,3‐triazolediyl residues, as new analogs of β ‐adrenoceptor antagonists is described ( Schemes 1 – 4 ). The synthesis of these compounds was achieved in four to five steps. The formation of oximes of 9 H ‐fluoren‐9‐one and benzophenone, i.e. , 9a and 9b , respectively, followed by their reaction with propargyl bromide, afforded O ‐propargyl oximes 10a and 10b , respectively, which by a subsequent CuI‐catalyzed Huisgen cycloaddition with prepared β ‐azido alcohols 11a – 11j ( Schemes 2 and 3 ), led to the target compounds 7a – 7t in good yields.