Regioselective Arylation and Alkynylation of 2,3‐Dibromo‐1 H ‐inden‐1‐one by  Suzuki  Miyaura  and  Sonogashira  Cross‐Coupling Reactions | Zendy

Khera Rasheed Ahmad | Zendy; Hussain Munawar | Zendy; Hung Nguyen Thai | Zendy; Eleya Nadi | Zendy; Feist Holger | Zendy; Villinger Alexander | Zendy; Langer Peter | Zendy

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Regioselective Arylation and Alkynylation of 2,3‐Dibromo‐1 H ‐inden‐1‐one by Suzuki  Miyaura and Sonogashira Cross‐Coupling Reactions

Author(s) -

Khera Rasheed Ahmad,

Hussain Munawar,

Hung Nguyen Thai,

Eleya Nadi,

Feist Holger,

Villinger Alexander,

Langer Peter

Publication year - 2012

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201100315

Subject(s) - chemistry , sonogashira coupling , regioselectivity , alkynylation , steric effects , coupling reaction , medicinal chemistry , palladium , organic chemistry , combinatorial chemistry , catalysis

Suzuki Miyaura reactions of 2,3‐dibromo‐1 H‐ inden‐1‐one afforded a wide range of arylated 1 H‐ inden‐1‐ones. Sonogashira cross‐coupling reactions gave alkynylated indenones. The reactions proceeded with very good regioselectivity in the less sterically hindered and more electron‐deficient position 3.

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