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Regioselective Arylation and Alkynylation of 2,3‐Dibromo‐1 H ‐inden‐1‐one by Suzuki Miyaura and Sonogashira Cross‐Coupling Reactions
Author(s) -
Khera Rasheed Ahmad,
Hussain Munawar,
Hung Nguyen Thai,
Eleya Nadi,
Feist Holger,
Villinger Alexander,
Langer Peter
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100315
Subject(s) - chemistry , sonogashira coupling , regioselectivity , alkynylation , steric effects , coupling reaction , medicinal chemistry , palladium , organic chemistry , combinatorial chemistry , catalysis
Suzuki Miyaura reactions of 2,3‐dibromo‐1 H‐ inden‐1‐one afforded a wide range of arylated 1 H‐ inden‐1‐ones. Sonogashira cross‐coupling reactions gave alkynylated indenones. The reactions proceeded with very good regioselectivity in the less sterically hindered and more electron‐deficient position 3.