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Yalongenes A and B, Two New Cembranoids with Cytoprotective Effects from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller
Author(s) -
Yao LiGong,
Zhang HaiYan,
Liang LinFu,
Guo XianJun,
Mao ShuiChun,
Guo YueWei
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100278
Subject(s) - chemistry , coral , stereochemistry , oceanography , geology
Two new cembranoids, yalongenes A ( 1 ) and B ( 2 ), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller . Their structures were elucidated by detailed spectroscopic analysis (IR, MS, and NMR) and by comparison with a related model compound. Yalongenes 1 and 2 were evaluated for their cytoprotective effects on SH‐SY5Y cell injury induced by H 2 O 2 in vitro , and the result showed that only compound 1 had a significant cytoprotective activity at the concentration of 1 μ M .