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Multicomponent Transformation of Isoindoline‐1,3‐diimine (=1 H ‐Isoindole‐1,3(2 H )‐diimine), Acetylenic Esters, and Triphenylphosphine to Novel Dihydropyrimido[2,1‐ a ]isoindole Derivatives
Author(s) -
Baharfar Robabeh,
Mohajer Saadieh
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100257
Subject(s) - isoindole , diimine , chemistry , isoindoline , triphenylphosphine , medicinal chemistry , stereochemistry , catalysis , organic chemistry
The three‐component reaction of the zwitterions generated from dialkyl acetylenedicarboxylates (=dialkyl but‐2‐ynedioates and triphenylphosphine (Ph 3 P) with isoindoline‐1,3‐diimine (=1 H ‐isoindole‐1,3(2 H )‐diimine) is described ( Scheme 1 ). This reaction affords the corresponding special type of substituted dihydropyrimido[2,1‐ a ]isoindole derivatives in good yields without using any catalyst and activation ( Table ).