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Alkaloid and Anthraquinone Derivatives Produced by the Marine‐Derived Endophytic Fungus Eurotium rubrum
Author(s) -
Yan HuiJiao,
Li XiaoMing,
Li ChunShun,
Wang BinGui
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100255
Subject(s) - chemistry , alkaloid , anthraquinone , fungus , antifungal , stereochemistry , anthraquinones , plant use of endophytic fungi in defense , emodin , botany , organic chemistry , biochemistry , microbiology and biotechnology , biology
Cultivation of the fungal strain Eurotium rubrum , an endophytic fungus that was isolated from the inner tissue of the semi‐mangrove plant Hibiscus tiliaceus , resulted in the isolation of one new dioxopiperazine alkaloid, 12‐demethyl‐12‐oxo‐eurotechinulin B ( 1 ), and one new anthraquinone derivative, 9‐dehydroxyeurotinone ( 2 ), together with ten known compounds including variecolorin J ( 3 ), eurotechinulin B ( 4 ), variecolorin G ( 5 ), alkaloid E‐7 ( 6 ), cryptoechinuline G ( 7 ), isoechinulin B ( 8 ), 7‐isopentenylcryptoechinuline D ( 9 ), 2‐ O ‐methyl‐9‐dehydroxyeurotinone ( 10 ), emodin ( 11 ), and emodic acid ( 12 ). The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. Some of the purified compounds were evaluated for antibacterial, antifungal, and cytotoxic activities.