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Facile Synthesis, Single‐Crystal Structure, and Biological Evaluation of Novel Pyrazolo[5,1‐ d ][1,2,5]triazepin‐4‐ones
Author(s) -
Zheng LiangWen,
Xuan HongZhuan,
Liu YingRui,
Zhao BaoXiang,
Liu JinTing,
Miao JunYing
Publication year - 2012
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100249
Subject(s) - chemistry , crystallization , ring (chemistry) , crystal structure , stereochemistry , crystallography , combinatorial chemistry , organic chemistry
A facile ring‐enlargement reaction of 2,6‐diphenyl‐4 H ‐pyrazolo[5,1‐ c ][1,4]oxazin‐4‐one is described, generating the pyrazolo[5,1‐ d ][1,2,5]triazepin‐4‐ones in good yields. Structures of the prepared compounds were determined on the basis of IR, 1 H‐ and 13 C‐NMR, and HR‐MS data. Moreover, the molecular structure was confirmed by the X‐ray crystal‐structure analysis of one compound that was prone to crystallization. Preliminary biological evaluation showed that the compounds 2e – 2h promote the viability and inhibit the apoptosis of vascular endothelial cells at low concentration.