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Two New 3,4‐Seco‐ ent ‐kaurenes and Other Constituents from the Costa Rican Endemic Species Croton megistocarpus
Author(s) -
Mora Soledad,
Castro Victor,
Poveda Luis,
Chavarría Max,
Murillo Renato
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100127
Subject(s) - diterpene , euphorbiaceae , chemistry , croton , phytochemical , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , terpene , traditional medicine , botany , organic chemistry , biology , medicine , biochemistry
Following our phytochemical studies of Costa Rican plants, we report the isolation of two new 3,4‐seco‐ ent ‐kaurenes from the aerial parts of Croton megistocarpus (Euphorbiaceae). The structures of the two compounds were elucidated as 14‐[(2‐methylbutanoyl)oxy]‐3,4‐seco‐ ent‐ kaura‐4(19),16‐dien‐3‐oic acid ( 1 ) and 14‐{[(2 Z )‐2‐methylbut‐2‐enoyl]oxy}‐3,4‐seco‐ ent‐ kaura‐4(19),16‐dien‐3‐oic acid ( 2 ). In addition, seven known diterpene clerodanes were also isolated and identified. The structures of the compounds were elucidated by spectroscopic methods, including HR‐MS, 1 H‐NMR, 13 C‐NMR, COSY, HMQC, HMBC, and NOESY experiments.