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A New Anthraquinone and Two New Tetrahydroanthraquinones from the Roots of Prismatomeris connata
Author(s) -
Feng ShiXiu,
Hao Jing,
Chen Tao,
Qiu Samuel X. ;Shengxiang
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100108
Subject(s) - anthraquinones , chemistry , anthraquinone , stereochemistry , cytotoxicity , cancer cell lines , cell culture , cancer cell , organic chemistry , biochemistry , cancer , botany , in vitro , medicine , genetics , biology
A new anthraquinone, 4‐hydroxy‐1,2,3‐trimethoxy‐6‐methylanthracene‐9,10‐dione ( 1 ), and two novel tetrahydroanthraquinones, prisconnatanones A and B ( 2 and 3 , resp.), together with 15 known anthraquinones, 4 – 18 , were isolated from the roots of Prismatomeris connata. Their structures were elucidated on the basis of spectroscopic data. Compounds 1 – 18 were evaluated for their cytotoxicity against A549 and LAC human cancer cell lines. Compound 2 and the anthraquinones with free OH groups exhibited activity against the test cell lines.