Premium
Synthesis of 9,9‐Disubstituted 9 H ‐Pyrrolo[1,2‐ a ]indoles by Hydriodic Acid‐Catalyzed Cyclization of 1‐[2‐(1‐Aryl(or methyl)ethenyl)phenyl]‐1 H ‐pyrroles
Author(s) -
Kobayashi Kazuhiro,
Hashimoto Kenichi,
Hashimoto Hiroo,
Kondo Hideaki,
Konishi Hisatoshi
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100091
Subject(s) - chemistry , catalysis , aryl , medicinal chemistry , organic chemistry , alkyl
A novel method is reported for the synthesis of 9,9‐disubstituted 9 H ‐pyrrolo[1,2‐ a ]indoles. Cyclization of 1‐[2‐(1‐aryl(or methyl)ethenyl)phenyl]‐1 H ‐pyrroles, which can be easily prepared from 2‐(1‐aryl(or methyl)ethenyl)anilines, proceeds smoothly, in general, at 0° in the presence of a catalytic (or an equimolar) amount of HI in MeCN to provide the desired products.