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New Cytochalasins from the Marine‐Derived Fungus Xylaria sp. SCSIO 156
Author(s) -
Chen Ziming,
Huang Hongbo,
Chen Yuchan,
Wang Zhongwen,
Ma Junying,
Wang Bo,
Zhang Weimin,
Zhang Changsheng,
Ju Jianhua
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100051
Subject(s) - cytochalasin , chemistry , fungus , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , cytotoxicity , cytochalasin b , cytochalasin d , in vitro , botany , cell , biochemistry , cytoskeleton , biology
Two new cytochalasins, 18‐deoxycytochalasin Q ( 1 ) and 21‐ O ‐deacetylcytochalasin Q ( 2 ), together with four known analogues, cytochalasin Q ( 3 ), 19,20‐epoxycytochalasin Q ( 4 ), 21‐ O ‐deacetyl‐19,20‐epoxycytochalasin Q ( 5 ), and cytochalasin D ( 6 ), were isolated from the fungus Xylaria sp. SCSIO156 originated from the South China Sea marine sediment. The structures of 1 and 2 were elucidated by MS and 1D‐ and 2D‐NMR data analyses, and comparison with known compounds. The known compounds 3 – 6 were identified by comparison of their MS and NMR data with those reported in the literature. In the in vitro antitumor assay, compounds 2 – 6 showed mild cytotoxicity against three tumor cell lines (MCF‐7, SF‐268, and NCI‐H460).