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Synthesis of β ‐Hydroxy α ‐Sulfanyl Esters by Using Nanocrystalline Magnesium Oxide
Author(s) -
Mahendar Koosam,
Sarma A. V. S.,
Raghavaiah P.,
Kantam Mannepalli Lakshmi,
Klabunde Kenneth J.
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100012
Subject(s) - sulfanyl , chemistry , sulfonium , nanocrystalline material , aldol reaction , magnesium , reagent , medicinal chemistry , group (periodic table) , thio , organic chemistry , salt (chemistry) , crystallography , catalysis
Aldol‐type reaction between electron deficient aldehydes and sulfonium salts to afford the corresponding β ‐hydroxy α ‐sulfanyl esters in moderate‐to‐good yields by using nanocrystalline MgO is described. The sulfanyl group is a useful group for further transformations in organic synthesis. Low R f ‐ value isomer is anti ‐configured as revealed by X‐ray diffraction study and consistent with the assignment of 1 H‐NMR spectrum.
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