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Allylation of N ‐Benzoylhydrazones (= N′ ‐Alkylidene‐Substituted Benzohydrazides) by Treatment with Allyl Bromide in the Presence of Zinc in Aqueous Ammonium Chloride Solution
Author(s) -
Das Biswanath,
Shinde Digambar Balaji,
Kanth Boddu Shashi,
Kumar Jayprakash Narayan
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201100006
Subject(s) - chemistry , aqueous solution , allyl bromide , bromide , ammonium chloride , zinc , ammonium bromide , chloride , allyl chloride , zinc bromide , ammonium , medicinal chemistry , nuclear chemistry , inorganic chemistry , organic chemistry , pulmonary surfactant , catalysis , biochemistry
N ‐Benzoylhydrazones (= N′ ‐alkylidene‐substituted benzohydrazides) 1 are allylated efficiently by reaction with allyl bromide ( 2 ) in the presence of Zn in aqueous NH 4 Cl solution. The products 3 are formed in excellent yields (85–94%) within 35–50 min ( Scheme, Table ).