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Three New 3,6‐Dioxygenated Diketopiperazines from the Basidiomycete Lepista sordida
Author(s) -
Chen XiangLian,
Wu Min,
Ti HuiHui,
Wei XiaoYi,
Li TaiHui
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000455
Subject(s) - diketopiperazines , chemistry , hela , stereochemistry , biochemistry , cell
Three new 3,6‐dioxygenated diketopiperazines, lepistamides A–C ( 1 – 3 ), along with a known compound, diatretol ( 4 ), were isolated from the mycelial solid cultures of the basidiomycete Lepista sordida. Their structures were elucidated by spectroscopic means. The isolated diketopiperazines were evaluated for the cytotoxic activity against Astc‐a‐1, Bel 7402, and HeLa cell lines, and their biogenetic pathway was discussed.