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Three New Diterpenoids from Isodon nervosus
Author(s) -
Wei ZhiXiong,
Gao YouHeng,
Yang Fen,
Lu HaiXiao,
Ni Lin,
Zhou XiaoHong
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000429
Subject(s) - chemistry , cytotoxicity , hela , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , diterpene , terpene , cell , biochemistry , in vitro
Three new ent ‐kaurane diterpenoids, rabdonervosins D–F ( 1 – 3 ), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated on the basis of spectroscopic methods including 1D‐ and 2D‐NMR analyses. Compounds 1 – 3 were evaluated for their cytotoxicity against HepG2, CNE2, PC‐9/ZD, HeLa, MCF‐7, and HCT116 cell lines. No compounds exhibited potent cytotoxicity.