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Asymmetric Total Synthesis of Stagonolide G
Author(s) -
Ramesh Dasari,
Rajaram Singanaboina,
Prabhakar Peddikotla,
Ramulu Udugu,
Kumar Reddy Dorigondla,
Venkateswarlu Yenamandra
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000416
Subject(s) - chemistry , stereocenter , regioselectivity , dihydroxylation , ring closing metathesis , metathesis , ring (chemistry) , stereochemistry , total synthesis , epoxide , salt metathesis reaction , enantioselective synthesis , catalysis , organic chemistry , polymer , polymerization
A simple asymmetric total synthesis of stagonolide G ( 1 ) is described. Asymmetric dihydroxylation, regioselective epoxide ring opening, and vinyl Grignard reactions are involved in generating the stereogenic centers C(4) and C(8), followed by Grubbs‐II‐ catalyzed ring‐closing metathesis (RCM).