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Polyoxygenated Sterols from Freshwater Clam
Author(s) -
Kong ZweLing,
Chi Yu Siauo,
Ai Dai Shu,
Tu ChaChung,
Pan MinHsiung,
Liu YeukChuen
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000405
Subject(s) - chemistry , corbicula fluminea , sterol , shellfish , triol , stereochemistry , biochemistry , environmental chemistry , fish <actinopterygii> , fishery , organic chemistry , aquatic animal , cholesterol , diol , biology
Two new biologically active polyoxygenated sterols, 3,5,9‐trihydroxycholest‐7‐en‐6‐one ( 1 ) and cholest‐7‐ene‐3,6,9‐triol ( 3 ), together with one known sterone, topsentisterol D3 ( 2 ), were isolated from freshwater clam ( Corbicula fluminea Muller ; an important cultured edible shellfish in Taiwan). The structure elucidation of sterols 1 – 3 were accomplished by 1 H‐ and 13 C‐NMR, HMQC, and HMBC, and MS analyses. The sterols 1 – 3 displayed cytotoxicities against the human hepatoma Hep G2 cells ( IC 50 : 6.04±0.07, 40.78±4.28, and 10.57±0.51 μg/ml, resp.).