Polyoxygenated Sterols from Freshwater Clam | Zendy

Kong ZweLing | Zendy; Chi Yu Siauo | Zendy; Ai Dai Shu | Zendy; Tu ChaChung | Zendy; Pan MinHsiung | Zendy; Liu YeukChuen | Zendy

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Polyoxygenated Sterols from Freshwater Clam

Author(s) -

Kong ZweLing,

Chi Yu Siauo,

Ai Dai Shu,

Tu ChaChung,

Pan MinHsiung,

Liu YeukChuen

Publication year - 2011

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201000405

Subject(s) - chemistry , corbicula fluminea , sterol , shellfish , triol , stereochemistry , biochemistry , environmental chemistry , fish <actinopterygii> , fishery , organic chemistry , aquatic animal , cholesterol , diol , biology

Two new biologically active polyoxygenated sterols, 3,5,9‐trihydroxycholest‐7‐en‐6‐one ( 1 ) and cholest‐7‐ene‐3,6,9‐triol ( 3 ), together with one known sterone, topsentisterol D3 ( 2 ), were isolated from freshwater clam ( Corbicula fluminea Muller ; an important cultured edible shellfish in Taiwan). The structure elucidation of sterols 1 – 3 were accomplished by 1 H‐ and 13 C‐NMR, HMQC, and HMBC, and MS analyses. The sterols 1 – 3 displayed cytotoxicities against the human hepatoma Hep G2 cells ( IC 50 : 6.04±0.07, 40.78±4.28, and 10.57±0.51 μg/ml, resp.).

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