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Antimicrobial Depsides Produced by Cladosporium uredinicola , an Endophytic Fungus Isolated from Psidium guajava Fruits
Author(s) -
de Medeiros Lívia Soman,
Murgu Michael,
de Souza Antônia Q. L.,
RodriguesFo. Edson
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000387
Subject(s) - chemistry , staphylococcus aureus , antimicrobial , psidium , fungus , plant use of endophytic fungi in defense , escherichia coli , microbiology and biotechnology , bacteria , botany , biology , organic chemistry , biochemistry , genetics , gene
Four depsides, all of them new as natural products, were isolated from Cladosporium uredinicola solid‐media culture and identified as 3‐hydroxy‐2,5‐dimethylphenyl 2,4‐dihydroxy‐3,6‐dimethylbenzoate ( 1 ), 3‐hydroxy‐2,4,5‐trimethylphenyl 2,4‐dihydroxy‐3,6‐dimethylbenzoate ( 2 ), 3‐hydroxy‐2,5‐dimethylphenyl 3‐[(2,4‐dihydroxy‐3,6‐dimethylbenzoyl)oxy]‐6‐hydroxy‐2,4‐dimethylbenzoate ( 3 ), and 3‐hydroxy‐2,4,5‐trimethylphenyl 3‐[(2,4‐dihydroxy‐3,6‐dimethylbenzoyl)oxy]‐6‐hydroxy‐2,4‐dimethylbenzoate ( 4 ). The endophytic fungus was isolated from Psidium guajava fruits and cultivated over sterilized rice. The compounds 1 – 4 were purified by classical chromatographic procedures, and the chemical structures were identified by spectroscopic studies, mainly 1D‐ and 2D‐NMR and LC/ESI‐MS/MS. Three of the isolated depsides exhibited moderate bacteriostatic and/or bactericide effects on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa , and Bacillus subtillis.