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New Polyketides Isolated from Botryosphaeria australis Strain ZJ12‐1A
Author(s) -
Xu YuHang,
Lu ChunHua,
Zheng ZhongHui,
Shen YueMao
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000345
Subject(s) - chemistry , antimicrobial , stereochemistry , strain (injury) , botryosphaeria , fermentation , mass spectrometry , derivative (finance) , botryosphaeria dothidea , organic chemistry , botany , chromatography , medicine , financial economics , economics , biology
Four new polyketides, botryosphaerones A–D ( 1 – 4 , resp.), were obtained from the fermentation culture of Botryosphaeria australis strain ZJ12‐1A, together with four known compounds, O ‐methylasparvenone ( 5 ), 6‐ethyl‐2,7‐dimethoxyjuglon ( 6 ) and its monoacetyl derivative 7 , and O ‐methylaspmenone ( 8 ). Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments, and HR‐Q‐TOF mass spectrometry, and by comparison with reported data. All compounds were evaluated for their cytotoxic and antimicrobial activities in vitro. Only compounds 6 and 7 showed cytotoxic and antimicrobial activities, as already reported.