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A Concise Route to Valacyclovir Hydrochloride
Author(s) -
Vetukuri Prasada Raju V. N. K. V.,
Vedantham Ravindra,
Thippannachar Mathad Vijayavitthal,
Reddy Padi Pratap,
Anand Ramasamy Vijaya
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000303
Subject(s) - chemistry , prodrug , hydrochloride , combinatorial chemistry , coupling (piping) , reduction (mathematics) , organic chemistry , biochemistry , mechanical engineering , geometry , mathematics , engineering
An efficient and concise synthesis of valacyclovir hydrochloride ( 4 ), which is a prodrug of acyclovir ( 3 ) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2 S )‐2‐azido‐3‐methylbutanoic acid followed by reduction ( Scheme 2 ).
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