Premium
Ophiobolin Sesterterpenoids and Pyrrolidine Alkaloids from the Sponge‐Derived Fungus Aspergillus ustus
Author(s) -
Liu HongBing,
EdradaEbel RuAngelie,
Ebel Rainer,
Wang Yao,
Schulz Barbara,
Draeger Siegfried,
Müller Werner E. G.,
Wray Victor,
Lin WenHan,
Proksch Peter
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000283
Subject(s) - chemistry , sponge , stereochemistry , fungus , aspergillus , microbiology and biotechnology , botany , biology
Abstract Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin‐type sesterterpenoids 1 – 5 and the two new pyrrolidine alkaloids 6 and 7 , together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic‐data analysis (1D‐ and 2D‐NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.