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Kadsufolins A – D and Related Cytotoxic Lignans from Kadsura oblongifolia
Author(s) -
Huang Zehao,
Lu Yan,
Liu Yinan,
Bastow Kenneth F.,
Lee Kuohsiung,
Chen Daofeng
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000259
Subject(s) - du145 , chemistry , cytotoxic t cell , stereochemistry , carcinoma , epidermoid carcinoma , cancer , biochemistry , cancer cell , in vitro , biology , genetics , lncap
Kadsufolins A–D ( 1 – 4 , resp.), four new dibenzocyclooctane‐type lignans, were isolated from the roots and stems of Kadsura oblongifolia , together with eleven known lignans. Their structures and configurations were elucidated by spectroscopic methods including 2D‐NMR techniques. The compounds were also evaluated for cytotoxic activity against human tumor cell lines A549 (lung carcinoma), DU145 (prostate carcinoma), KB (epidermoid carcinoma of the nasopharynx), and HCT‐8 (ileocecal carcinoma). Kadsufolin A ( 1 ), kadsufolin D ( 4 ), angeloylbinankadsurin A, and heteroclitin B were found to show cytotoxic activities against A549, DU145, KB and HCT‐8 with GI 50 values of 5.1–20.0 μg/ml.