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Novel Four‐Component Approach for the Synthesis of Polyfunctionalized 1,4‐Dihydropyridines in Aqueous Media
Author(s) -
Hadjebi Melika,
Hashtroudi Mehri S.,
Bijanzadeh Hamid Reza,
Balalaie Saeed
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000228
Subject(s) - chemistry , malononitrile , dimethyl acetylenedicarboxylate , aqueous solution , aqueous medium , component (thermodynamics) , catalysis , base (topology) , organic chemistry , dihydropyridine , combinatorial chemistry , calcium , mathematical analysis , physics , mathematics , cycloaddition , thermodynamics
The four‐component reaction of dimethyl acetylenedicarboxylate (=dimethyl but‐2‐ynedioate; DMAD), aromatic aldehydes, and malononitrile (=propanedinitrile) leads to polyfunctionalized 1,4‐dihydropyridine derivatives. The reaction proceeds at room temperature and in the presence of a catalytic amount (20%) of (NH 4 ) 2 HPO 4 as a base in aqueous media.
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