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The Reaction of ( N ‐Isocyanimino)triphenylphosphorane with Biacetyl in the Presence of Aromatic Carboxylic Acids: Efficient One‐Pot Three‐Component Reaction for the Synthesis of 3‐(5‐Aryl‐1,3,4‐oxadiazol‐2‐yl)‐3‐hydroxybutan‐2‐one Derivatives
Author(s) -
Ramazani Ali,
Rouhani Morteza,
Rezaei Aram,
Shajari Nahid,
Souldozi Ali
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000219
Subject(s) - chemistry , aryl , butane , organic chemistry , component (thermodynamics) , medicinal chemistry , carboxylic acid , catalysis , alkyl , physics , thermodynamics
Abstract Reactions of biacetyl (=butane‐2,3‐dione) with ( N ‐isocyanimino)triphenylphosphorane in the presence of aromatic carboxylic acids proceed smoothly at room temperature and under neutral conditions to afford 3‐(5‐aryl‐1,3,4‐oxadiazol‐2‐yl)‐3‐hydroxybutan‐2‐one derivatives in high yields.