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Two New Sesquiterpenes from Inula salsoloides and Their Inhibitory Activities against NO Production
Author(s) -
Hu XiaoJia,
Jin HuiZi,
Liu XiaoHua,
Zhang WeiDong
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000195
Subject(s) - chemistry , inula , inhibitory postsynaptic potential , stereochemistry , terpene , sesquiterpene , lipopolysaccharide , traditional medicine , medicine , alternative medicine , pathology , traditional chinese medicine , neuroscience , biology , endocrinology
Two new sesquiterpenes, inulasalene ( 1 ) and inulasalsolide B ( 2 ), as well as 22 known compounds were isolated from the aerial parts of Inula salsoloides. The structures of the new sesquiterpenes were determined on the basis of their spectroscopic data and chemical properties. Compounds 1 – 4 exhibited potent inhibitory activities against NO production with IC 50 values range of 0.010–1.290 μg/ml in lipopolysaccharide (LPS)‐stimulated RAW264.7 cells.