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Facile Synthesis of Substituted Ethyl 2‐(Chloromethyl)‐2‐hydroxy‐2 H ‐1‐benzopyran‐3‐carboxylates
Author(s) -
Raju Bhimapaka China,
Saidachary Gannerla,
Kumar Jaladi Ashok,
Sridhar Balasubramanian
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000181
Subject(s) - chemistry , piperidine , benzopyran , medicinal chemistry , organic chemistry
Ethyl 2‐(chloromethyl)‐2‐hydroxy‐2 H ‐chromene‐3‐carboxylates 2a – 2j have been synthesized by reaction of substituted salicylaldehydes with ethyl 4‐chloro‐3‐oxobutanoate, in the presence of piperidine in CH 2 Cl 2 at room temperature, in good yields.