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An Iterative Acetylene–Epoxide Coupling Strategy for the Total Synthesis of Aspinolide A
Author(s) -
Sabitha Gowravaram,
Reddy Teega Rammohan,
Srinivas Chitti,
Yadav Jhillu Singh
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000161
Subject(s) - chemistry , epoxide , acetylene , total synthesis , coupling (piping) , key (lock) , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , mechanical engineering , ecology , engineering , biology
The total synthesis of aspinolide A ( 1 ) was successfully achieved by an iterative acetyleneepoxide coupling strategy and a Yamaguchi lactonization as the key steps.