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Three New Eudesmanolactones (=Eudesmanolides) from Camchaya loloana
Author(s) -
Li ChangSong,
Yu HongWei,
Chen XiaoZhen,
Wu XiaoQing,
Li GuoYou,
Zhang GuoLin
Publication year - 2011
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000138
Subject(s) - chemistry , hydroxymethyl , stereochemistry , cytotoxicity , biochemistry , in vitro
Three new eudesmanolactones (=eudesmanolides), loloanolide A ( 1 ), loloanolide B ( 2 ), and 1‐ O ‐acetylloloanolide B ( 3 ), together with five known compounds, were isolated from the CHCl 3 extract of the aerial parts of Camchaya loloana. Their structures were elucidated on the basis of spectroscopic analysis. This type of eudesmanolactones bearing a 2‐(hydroxymethyl)acryloyloxy group at C(8) was discovered for the first time. Compounds 1 – 3 exhibited cytotoxicity against the HepG2 cell line, with GI 50 values of 22.9, 18.1, and 12.8 nmol/ml, respectively.