Three New Eudesmanolactones (=Eudesmanolides) from  Camchaya loloana | Zendy

Li ChangSong | Zendy; Yu HongWei | Zendy; Chen XiaoZhen | Zendy; Wu XiaoQing | Zendy; Li GuoYou | Zendy; Zhang GuoLin | Zendy

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Three New Eudesmanolactones (=Eudesmanolides) from Camchaya loloana

Author(s) -

Li ChangSong,

Yu HongWei,

Chen XiaoZhen,

Wu XiaoQing,

Li GuoYou,

Zhang GuoLin

Publication year - 2011

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.201000138

Subject(s) - chemistry , hydroxymethyl , stereochemistry , cytotoxicity , biochemistry , in vitro

Three new eudesmanolactones (=eudesmanolides), loloanolide A ( 1 ), loloanolide B ( 2 ), and 1‐ O ‐acetylloloanolide B ( 3 ), together with five known compounds, were isolated from the CHCl 3 extract of the aerial parts of Camchaya loloana. Their structures were elucidated on the basis of spectroscopic analysis. This type of eudesmanolactones bearing a 2‐(hydroxymethyl)acryloyloxy group at C(8) was discovered for the first time. Compounds 1 – 3 exhibited cytotoxicity against the HepG2 cell line, with GI 50 values of 22.9, 18.1, and 12.8 nmol/ml, respectively.

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