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Eleven New Triterpenes from Eurycorymbus cavaleriei
Author(s) -
Cheng Lin,
Shen LiMing,
Zhang Min,
Li Ning,
Li Xian,
Ma ZhongJun,
Qu HaiBin
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000131
Subject(s) - chemistry , dammarane , terpene , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , cytotoxicity , quinone , tandem mass spectrometry , tandem , mass spectrometry , in vitro , triterpene , chromatography , biochemistry , medicine , alternative medicine , pathology , materials science , composite material
Eleven new triterpenes, cavalerols A–K ( 1 – 11 , resp.), ten of which were derivatives of hopane and one was derivative of dammarane, were isolated from the twigs of Eurycorymbus cavaleriei. Their structures were elucidated by spectroscopic methods including 2D‐NMR analysis. Cavalerol D ( 4 ) and cavalerol F ( 6 ), cavalerol B ( 2 ), and cavalerol G ( 7 ) were two pairs of isomers, and silver ion was introduced for their differentiation by multi‐stage tandem mass spectrometry. And nine compounds, except 5 and 10 , were tested for quinone reductase (QR) induction activities in vitro , and results showed that compounds 2, 4 , and 7 exhibited moderate induction activities with CD values of 8.62, 9.13, and 2.56 μg/ml, respectively, and compounds 6 and 8 showed cytotoxicity against hepa 1c1c7 cell line with IC 50 values of no more than 1 μg/ml.