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A New Antifungal Cyclic Lipopeptide from Bacillus marinus B‐9987
Author(s) -
Liu RongFeng,
Zhang DaoJing,
Li YuanGuang,
Tao LiMing,
Tian Li
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000094
Subject(s) - lipopeptide , chemistry , fermentation , bioassay , antifungal , cyclic peptide , stereochemistry , bacteria , chromatography , food science , microbiology and biotechnology , peptide , biochemistry , biology , ecology , genetics
A new cyclic lipopeptide, marihysin A ( 1 ), along with the three known cyclodipeptides cyclo(Ala‐Ile) ( 2 ), cyclo(Ala‐Leu) ( 3 ), and cyclo(Ala‐Tyr) ( 4 ), was isolated from the fermentation broth of the marine microorganism Bacillus marinus B‐9987 isolated from the tissues of rhizophere of Suaeda salsa in the intertidal zone of the Bohai Bay of P. R. China. Marihysin A ( 1 ) was established to be cyclo(Pro‐Gln‐Asn 1 ‐Ser‐Asn 2 ‐Tyr‐Asn 3 ‐ β ‐aminotetradecanoic acid) by spectroscopic analysis, and it exhibits broad‐spectrum but low activity against plant pathogens as determined by antifungal bioassay.