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A Novel 1‐Glycosyl‐1 H ‐triazole‐Based P , N Ligand for Rhodium‐Catalyzed Asymmetric Hydrosilylation of Ketones
Author(s) -
Shen Chao,
Zhang PengFei,
Chen XinZhi
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000093
Subject(s) - hydrosilylation , chemistry , acetophenone , enantioselective synthesis , rhodium , glycosyl , ligand (biochemistry) , catalysis , triazole , stereochemistry , medicinal chemistry , organic chemistry , combinatorial chemistry , biochemistry , receptor
A novel class of chiral glycosyl‐triazole‐based P , N ligands were synthesized by ‘click chemistry’ and were applied to the Rh‐catalyzed asymmetric hydrosilylation of a range of substituted acetophenones. Enantioselective hydrosilylation of acetophenone gave ( S )‐1‐phenylethanol in moderate enantioselectivity (72% ee) and in good conversion (93%).