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Cytotoxic Triterpenoid Saponins Acetylated with Monoterpenoid Acid from Albizia julibrissin
Author(s) -
Zou Kun,
Zhang QingYing,
Wang Bin,
Cui JingRong,
Zhao YuYing,
Zhang RuYi
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000059
Subject(s) - chemistry , aglycone , triterpenoid saponin , acetylation , saponin , albizia , oleanane , cancer cell lines , triterpenoid , terpene , terpenoid , stereochemistry , triterpene , glycoside , traditional medicine , biochemistry , cancer cell , cancer , medicine , alternative medicine , pathology , gene
Three new triterpenoid saponins, named julibroside J 16 ( 2 ), julibroside J 17 ( 3 ), and julibroside J 21 ( 4 ), each of which possesses an oleanane triterpenoid aglycone of acacic acid, two monoterpenoid acids, and nine sugar moieties, together with one known saponin, julibroside II ( 1 ), were isolated from the stem bark of Albizia julibrissin by chromatographic methods. Their structures were established by chemical and spectroscopic means. Saponins 1, 2 , and 4 showed inhibitory activities against Bel 7402 human cancer cell line in vitro.