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Oligonucleotide Analogues with Integrated Bases and Backbones. Part 23
Author(s) -
Bogliotti Nicolas,
Bernet Bruno,
Vasella Andrea
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000008
Subject(s) - chemistry , oligonucleotide , sulfone , association (psychology) , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , dna , epistemology , philosophy
The sulfone 2 , and the sulfoxides ( S )‐ 3 and ( R )‐ 3 were obtained by oxidation of the thiomethylene‐linked A*[ s ]U dinucleoside 1 . Conformational analysis and association studies of 2 , ( S )‐ 3 , and ( R )‐ 3 reveal a strong influence of the configuration on the conformation of the linking unit and on the self‐association of the dinucleosides.