Premium
Oligonucleotide Analogues with Integrated Bases and Backbones. Part 23
Author(s) -
Bogliotti Nicolas,
Bernet Bruno,
Vasella Andrea
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000008
Subject(s) - chemistry , oligonucleotide , sulfone , association (psychology) , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , dna , epistemology , philosophy
The sulfone 2 , and the sulfoxides ( S )‐ 3 and ( R )‐ 3 were obtained by oxidation of the thiomethylene‐linked A*[ s ]U dinucleoside 1 . Conformational analysis and association studies of 2 , ( S )‐ 3 , and ( R )‐ 3 reveal a strong influence of the configuration on the conformation of the linking unit and on the self‐association of the dinucleosides.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom