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Four New Nortriterpenoids from Schisandra lancifolia
Author(s) -
Xiao WeiLie,
Wu YingLi,
Shang ShanZhai,
He Fei,
Luo Xiao,
Yang GuangYu,
Pu JianXin,
Chen GuoQiang,
Sun HanDong
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.201000004
Subject(s) - chemistry , cytotoxicity , mass spectrometry , schisandra chinensis , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , biochemistry , chromatography , in vitro , medicine , alternative medicine , traditional chinese medicine , pathology
Four new highly oxygenated nortriterpenoids, lancifodilactones O–R ( 1 – 4 ), together with six known ones, i.e. , 5 – 10 , were isolated from the leaves and stems of Schisandra lancifolia. Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments and mass spectrometry. Compounds 1 – 3 were evaluated for their cytotoxicity against NB4, A549, SHSY5Y, PC‐3, and MCF‐7 cell lines. No compounds exhibited significant cytotoxicity, the IC 50 values being above 50 μ M .