Premium
Anthraquinones and Lignans from Cassia occidentalis
Author(s) -
Li ShiFei,
Di YingTong,
Wang YueHu,
Tan ChengJian,
Fang Xin,
Zhang Yu,
Zheng YongTang,
Li Ling,
He HongPing,
Li ShunLin,
Hao XiaoJiang
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900460
Subject(s) - chemistry , emodin , cassia , anthraquinones , anthraquinone , glycoside , stereochemistry , traditional medicine , chromatography , organic chemistry , botany , traditional chinese medicine , medicine , alternative medicine , pathology , biology
One new anthraquinone glycoside, 6‐ O ‐( α ‐ L ‐rhamnopyranosyl‐(1→6)‐ β ‐ d‐ glucopyranosyl)emodin ( 1 ), and two new sesquilignans, seslignanoccidentaliols A ( 2 ) and B ( 3 ), were isolated from the whole plant of Cassia occidentalis. The structures of the new compounds were established by means of spectroscopic methods, especially 2D‐NMR data ( 1 H, 1 H‐COSY, HMQC, HMBC, and ROESY), as well as HR‐ESI‐MS analysis. One previously reported sesquilignan, erythro ‐guaiacylglycerol‐ β ‐ O ‐4′‐(5′)‐methoxylariciresinol, was revised to be seslignanoccidentaliol A ( 2 ). The 6‐ O ‐( α ‐ L ‐rhamnopyranosyl‐(1→6)‐ β ‐ d‐ glucopyranosyl)emodin ( 1 ) exhibited moderate anti‐HIV‐1 activity with an EC 50 value of 2.90 μg/ml and a therapeutic‐index ( TI ) value of 260.