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New Chemical Constituents from Borreria verticillata (Rubiaceae)
Author(s) -
Moreira Vinicius F.,
Oliveira Rodrigo R.,
Mathias Leda,
BrazFilho Raimundo,
Curcino Vieira Ivo J.
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900457
Subject(s) - chemistry , rubiaceae , two dimensional nuclear magnetic resonance spectroscopy , phytochemical , indole test , stereochemistry , iridoid , glycoside , botany , biochemistry , biology
A phytochemical study on Borreria verticillata has led to the isolation of two novel simple indole alkaloids, 6‐methoxy‐4‐(3‐methylbut‐2‐en‐1‐yl)‐1 H ‐indole, named verticillatine A ( 1 ), and 1‐(1 H ‐indol‐6‐yl)‐3‐methylbutan‐1‐one, named verticillatine B ( 2 ), one new iridoid, 6′‐ O ‐(2‐glyceryl)scandoside methyl ester ( 3 ), with the glycerol unit linked to a glucose unit, and two known ones, asperuloside ( 4 ) and scandoside methyl ester ( 5 ). The structures of these compounds were elucidated on the basis of spectroscopic‐data analyses, mainly 1 H‐ and 13 C‐NMR, including 2D experiments ( 1 H, 1 H‐COSY, NOESY, HMBC, and HMQC), and HR‐ESI‐MS.