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Cytotoxic Evaluation of Pungencine: A New Tropane Alkaloid from the Roots of Erythroxylum pungens O. E. Schulz
Author(s) -
SenaFilho José G.,
da Silva Marcelo S.,
Tavares Josean F.,
Oliveira Steno L.,
Romero Marco A. V.,
Xavier Haroudo S.,
BarbosaFilho Jose M.,
BrazFilho Raimundo
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900434
Subject(s) - chemistry , stereochemistry , dept , two dimensional nuclear magnetic resonance spectroscopy , tropane , alkaloid , cytotoxicity , jurkat cells , t cell , biochemistry , in vitro , immune system , immunology , biology
A new tropane alkaloid as well as a new substitution group, (3‐ endo ,8‐ anti )‐8‐methyl‐8‐azabicyclo[3.2.1]oct‐3‐yl 4‐hydroxy‐3,5‐dimethoxybenzoate, called pungencine ( 1 ), was isolated from the roots of Erythroxylum pungens O. E. Schulz . The structure was elucidated by spectral analyses, including 1 H‐ and 13 C‐NMR and 2D‐NMR techniques ( 1 H, 1 H‐COSY, NOESY, DEPT, HMQC, and HMBC) and HR‐ESI‐MS. Furthermore, compound 1 was tested for cytotoxicity against several cell lines (Jurkat, HL‐60, U937, K562, KG‐1, and U266) and was determined not to inhibit cell viability at 10 μ M .
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