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A New Nortriterpene from the Root of Celastrus hypoleucus
Author(s) -
Wang Hong,
Tian Xuan,
Ying Guo Qing
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900426
Subject(s) - chemistry , tbars , lipid peroxidation , antioxidant , in vitro , cancer cell lines , stereochemistry , traditional medicine , organic chemistry , biochemistry , cancer cell , cancer , medicine
A new nortriterpene, 2‐hydroxy‐3‐methyl‐21‐oxo‐12,24‐dinor‐ D : B ‐friedooleana‐1,3,5(10),7‐tetraen‐29‐oic acid ( 1 ), was isolated from the root of Celastrus hypoleucus , together with the two known compounds, celastorol ( 2 ) and pristimerine ( 3 ). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 1 – 3 exhibited in vitro significant antioxidant (against lipid peroxidation; by the TBARS method) and antitumor activities (against cancer cell lines P‐388, A‐549, HL‐60, and BEL‐7402).