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Synthesis of Functionalized Tetrahydro‐4‐oxoindeno[1,2‐ b ]pyrroles from Ninhydrin, Acetylenedicarboxylates, and Primary Amines
Author(s) -
Yavari Issa,
Seyfi Samereh,
Nematpour Manijeh,
Hossaini Zinatossadat
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900408
Subject(s) - ninhydrin , chemistry , pyrrole , primary (astronomy) , medicinal chemistry , alkyl , hydrate , component (thermodynamics) , organic chemistry , combinatorial chemistry , biochemistry , amino acid , physics , astronomy , thermodynamics
Abstract A one‐pot synthesis of dialkyl 1,3a,4,8b‐tetrahydro‐3a,8b‐dihydroxy‐1‐alkyl‐4‐oxoindeno[1,2‐ b ]pyrrole‐2,3‐dicarboxylates via three‐component reaction from indan‐1,2,3‐trione hydrate (ninhydrin), primary amines, and dialkyl acetylenedicarboxylates is described.