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A One‐Pot Biginelli Synthesis of 6‐Unsubstituted 5‐Aroylpyrimidin‐2(1 H )‐ones and 6‐Acetyl‐1,2,4‐triazin‐3(2 H )‐ones
Author(s) -
Darwish Elham Sayed,
Abdelshafy Abdelhamid Ismail,
Adel Nasra Miead,
AbdelGallil Fathy Mohamed,
Fleita Daisy Hanna
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900355
Subject(s) - chemistry , benzaldehyde , hydrazone , acetic acid , urea , biginelli reaction , organic chemistry , medicinal chemistry , catalysis
The three‐component Biginelli ‐like cyclocondensation reaction of enamines 1 , urea, and aldehydes in dioxane/acetic acid efficiently afforded the corresponding 6‐unsubstituted 3,4‐dihydropyrimidin‐2(1 H )‐ones 2 in good yields ( Scheme 1, Table ). The corresponding reaction of azaenamine (=hydrazone) 7 with benzaldehyde and urea afforded 6‐acetyl‐1,2,4‐triazin‐3(2 H )‐ones in good yields ( Scheme 3 ).
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