A New Cardenolide and Two New Pregnane Glycosides from the Root Barks of Periploca sepium

A new cardenolide and two new pregnane glycosides, periplogenin 3‐[ O ‐ β ‐glucopyranosyl‐(1→4)‐ β ‐sarmentopyranoside] ( 1 ), (3 β ,20 S )‐pregn‐5‐ene‐3,17,20‐triol 20‐[ O ‐ β ‐glucopyranosyl‐(1→6)‐ O ‐glucopyranosyl‐(1→4)‐ β ‐canaropyranoside] ( 2 ), and (3 β ,14 β ,17 α )‐3,14,17‐trihydroxy‐21‐methoxypregn‐5‐en‐20‐one 3‐[ O ‐ β ‐oleandropyranosyl‐(1→4)‐ O ‐ β ‐cymaropyranosyl‐(1→4)‐ β ‐cymaropyranoside] ( 3 ), were isolated from the root barks of Periploca sepium Bge , together with seven related known compounds, periplogenin, xysmalogenin, (3 β ,20 S )‐pregn‐5‐ene‐3,17,20‐triol, (3 β ,14 β ,17 α )‐3,14,17‐trihydroxy‐21‐methoxypregn‐5‐en‐20‐one, (3 β ,20 S )‐pregn‐5‐ene‐3,20‐diol 3‐ β ‐glucopyranoside 20‐ β ‐glucopyranoside, (3 β ,20 S )‐pregn‐5‐ene‐3,20‐diol 3‐[ O ‐2‐ O ‐acetyl‐ β ‐digitalopyranosyl‐(1→4)‐ β ‐cymaropyranoside] 20‐[ O ‐ β ‐glucopyranosyl‐(1→6)‐ O ‐ β ‐glucopyranosyl‐(1→2)‐ β ‐digitalopyranoside], and (3 β ,20 S )‐ pregn‐5‐ene‐3,20‐diol 20‐[ O ‐ β ‐glucopyranosyl‐(1→6)‐ β ‐glucopyranoside]. Their structures were elucidated on the basis of spectroscopic analyses.