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A Novel and Efficient One‐Pot Synthesis of 2‐Aminopyrimidinones and Their Self‐Assembly
Author(s) -
Bararjanian Morteza,
Balalaie Saeed,
Rominger Frank,
Barouti Sanaz
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900319
Subject(s) - chemistry , benzaldehyde , hydrochloride , component (thermodynamics) , ethyl cyanoacetate , piperidine , organic chemistry , aryl , medicinal chemistry , malononitrile , catalysis , alkyl , physics , thermodynamics
A three‐component reaction of benzaldehyde derivatives, methyl cyanoacetate, and guanidinium carbonate affords 2‐amino‐4‐aryl‐1,6‐dihydro‐6‐oxopyrimidine‐5‐carbonitriles and the four‐component reaction of benzaldehyde derivatives, methyl cyanoacetate, and guanidinium hydrochloride in the presence of piperidine leads to piperidinium salts of pyrimidinones. X‐ray crystallography data confirm self‐assembly and H‐bonding in these compounds.