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A New Isofuranonaphthalenone and Benzopyrans from the Endophytic Fungus Nodulisporium sp. A4 from Aquilaria sinensis
Author(s) -
Wu ZhengChao,
Li DongLi,
Chen YuChan,
Zhang WeiMin
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900307
Subject(s) - chemistry , benzopyrans , fungus , stereochemistry , botany , biology
A new isofuranonaphthalenone, (7 R *,8 S *)‐3,6,7,8‐tetrahydro‐4,7,8‐trihydroxynaphtho[2,3‐ c ]furan‐5(1 H )‐one ( 1 ), and a new benzopyran, (2 R *,4 R *)‐3,4‐dihydro‐4‐methoxy‐2‐methyl‐2 H ‐1‐benzopyran‐5‐ol ( 2 ), together with four known related analogs, 3 – 6 , were isolated from the culture of Nodulisporium sp. A4, an endophytic fungus from the stem of Aquilaria sinensis ( Lour.) Gilg . The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. The isolated compounds 1 – 6 were evaluated for their cytotoxic activities against the NCI‐H460 and SF‐268 tumor cell lines.