Premium
New Cytotoxic Myrsinane‐Type Diterpenes from Euphorbia prolifera
Author(s) -
Li Jie,
Xu Liang,
Wang FengPeng
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900288
Subject(s) - chemistry , euphorbia , cytotoxicity , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , cytotoxic t cell , cancer cell lines , euphorbiaceae , diterpene , cancer cell , traditional medicine , botany , cancer , biochemistry , in vitro , biology , medicine
Four new myrsinol diterpenes, proliferins A–D ( 1 – 4 , resp.) were isolated from the EtOH extracts of the roots of Euphorbia prolifera , along with four known compounds, euphorprolitherin B ( 5 ), euphorprolitherin D ( 6 ), SPr5 ( 7 ), and 14‐desoxo‐3‐ O ‐propionyl‐5,15‐di‐ O ‐acetyl‐7‐ O ‐nicotinoylmyrsinol‐14 β ‐acetate ( 8 ). Their structures were established on the basis of spectroscopic methods, including HR‐ESI‐MS, and 1D‐ and 2D‐NMR techniques. The cytotoxicity of compounds 1, 3 , and 4 against cancer cells was evaluated, with compound 1 being active against A2780 cancer cells.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom