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New Cytotoxic Myrsinane‐Type Diterpenes from Euphorbia prolifera
Author(s) -
Li Jie,
Xu Liang,
Wang FengPeng
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900288
Subject(s) - chemistry , euphorbia , cytotoxicity , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , cytotoxic t cell , cancer cell lines , euphorbiaceae , diterpene , cancer cell , traditional medicine , botany , cancer , biochemistry , in vitro , biology , medicine
Four new myrsinol diterpenes, proliferins A–D ( 1 – 4 , resp.) were isolated from the EtOH extracts of the roots of Euphorbia prolifera , along with four known compounds, euphorprolitherin B ( 5 ), euphorprolitherin D ( 6 ), SPr5 ( 7 ), and 14‐desoxo‐3‐ O ‐propionyl‐5,15‐di‐ O ‐acetyl‐7‐ O ‐nicotinoylmyrsinol‐14 β ‐acetate ( 8 ). Their structures were established on the basis of spectroscopic methods, including HR‐ESI‐MS, and 1D‐ and 2D‐NMR techniques. The cytotoxicity of compounds 1, 3 , and 4 against cancer cells was evaluated, with compound 1 being active against A2780 cancer cells.