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Medicinal Flowers. Part 29 . Acylated Oleanane‐Type Triterpene Bisdesmosides: Perennisaponins G, H, I, J, K, L, and M with Pancreatic Lipase Inhibitory Activity from the Flowers of Bellis perennis
Author(s) -
Morikawa Toshio,
Li Xuezheng,
Nishida Eriko,
Nakamura Seikou,
Ninomiya Kiyofumi,
Matsuda Hisashi,
Oda Yoshimi,
Muraoka Osamu,
Yoshikawa Masayuki
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900258
Subject(s) - chemistry , triterpene , pancreatic lipase , stereochemistry , lipase , oleanane , enzyme , biochemistry , medicine , alternative medicine , pathology
The MeOH extract from the flowers of Bellis perennis was found to show pancreatic‐lipase inhibitory activity ( IC 50 455 μg/ml). From the extract, seven new triterpene saponins named perennisaponins G ( 1 ; IC 50 163 μ M ), H ( 2 ; 137 μ M ), I ( 3 ; 147 μ M ), J ( 4 ; 148 μ M ), K ( 5 ; 223 μ M ), L ( 6 ; 81.4 μ M ), and M ( 7 ; 195 μ M ) were isolated as pancreatic lipase inhibitors. The stereostructures of 1 – 7 were elucidated on the basis of chemical and spectroscopic evidence.