Premium
Comparative Studies of Different Quinolinone Derivatives as Donors in Fluorescence‐Resonance‐Energy Transfer (FRET) – Systems in Combination with a (Bathophenanthroline)ruthenium(II) Complex as Acceptor
Author(s) -
Kramer Rolf A.,
Flehr Roman,
Lay Myriam,
Kumke Michael U.,
Bannwarth Willi
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900235
Subject(s) - chemistry , förster resonance energy transfer , ruthenium , acceptor , fluorescence , photochemistry , combinatorial chemistry , energy transfer , resonance (particle physics) , organic chemistry , catalysis , chemical physics , physics , particle physics , quantum mechanics , condensed matter physics
We describe the preparation as well as a detailed photophysical study of Fmoc‐amino acid building blocks carrying different carbostyril (=quinolin‐2(1 H )‐one) heterocycles as donors in a FRET (fluorescence‐resonance‐energy transfer) system in combination with a [Ru II (bathophenanthroline)] complex (bathophenanthroline=4,7‐diphenyl‐1,10‐phenanthroline). The efforts resulted in a clear preference for building block 16 due to its ease of synthesis ( Scheme 2 ), its chemical robustness, and the FRET efficiency when incorporated into peptides.