Comparative Studies of Different Quinolinone Derivatives as Donors in Fluorescence‐Resonance‐Energy Transfer (FRET) – Systems in Combination with a (Bathophenanthroline)ruthenium(II) Complex as Acceptor | Zendy

Kramer Rolf A. | Zendy; Flehr Roman | Zendy; Lay Myriam | Zendy; Kumke Michael U. | Zendy; Bannwarth Willi | Zendy

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Comparative Studies of Different Quinolinone Derivatives as Donors in Fluorescence‐Resonance‐Energy Transfer (FRET) – Systems in Combination with a (Bathophenanthroline)ruthenium(II) Complex as Acceptor

Author(s) -

Kramer Rolf A.,

Flehr Roman,

Lay Myriam,

Kumke Michael U.,

Bannwarth Willi

Publication year - 2009

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200900235

Subject(s) - chemistry , förster resonance energy transfer , ruthenium , acceptor , fluorescence , photochemistry , combinatorial chemistry , energy transfer , resonance (particle physics) , organic chemistry , catalysis , chemical physics , physics , particle physics , quantum mechanics , condensed matter physics

We describe the preparation as well as a detailed photophysical study of Fmoc‐amino acid building blocks carrying different carbostyril (=quinolin‐2(1 H )‐one) heterocycles as donors in a FRET (fluorescence‐resonance‐energy transfer) system in combination with a [Ru II (bathophenanthroline)] complex (bathophenanthroline=4,7‐diphenyl‐1,10‐phenanthroline). The efforts resulted in a clear preference for building block 16 due to its ease of synthesis ( Scheme 2 ), its chemical robustness, and the FRET efficiency when incorporated into peptides.

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